Research

Elucidating Host–Vector–Virus Interactions in Mosquito-Borne Viral Infections

Mosquito-borne viruses such as dengue and Zika establish their infection cycles through complex interactions among mosquitoes, viruses, and mammalian hosts. We aim to uncover how these viruses replicate across different species and ultimately cause disease in humans. By revealing these cross-species mechanisms, we seek to develop novel strategies for infection control.

Analyzing the Impact of Immune Imprinting on Long-Term Immunity and Infection Protection

Immune memory induced by infection or vaccination shapes subsequent immune responses. In influenza, a phenomenon known as original antigenic sin has long been recognized, and similar immune imprinting has recently been reported for SARS-CoV-2. Our research investigates both the positive and negative impacts of immune imprinting on protection and vaccine efficacy, contributing to the design of next-generation vaccines.

Understanding the Effects of Environmental Factors on Viral Pathogenesis and Immune Responses

Environmental factors such as nutritional status, psychological stress, and circadian rhythm profoundly influence disease progression and vaccine responses following viral infection. We aim to elucidate how these factors modulate immune and infection dynamics and to establish personalized infection-control and vaccination strategies that take individual environments and lifestyles into account.

Beyond these core themes, our laboratory also engages in a variety of projects related to viral pathogenesis, vaccine development, and evaluation of vaccine efficacy in humans, contributing to a comprehensive understanding of viral infectious diseases.

GMP Education

There are many hurdles in translating seeds of innovation generated in academia into clinical applications. To address this, our laboratory is committed to strengthening GMP education as a bridge that connects basic scientific discoveries to societal implementation. Through these efforts, we aim to create an environment at UTOPIA that promotes active academia-driven vaccine development and pharmaceutical translation.